Xeomin is the latest competitor to go up against Botox and Dysport. Though Xeomin has been thriving on the global market since 2005, the product was not introduced in the United States until 2010. The FDA approved it in July 2011.
“Results appear to be quite similar to those of Botox and Dysport, and in fact, some patients report an even faster onset of results with Xeomin,” Dr. Calderon reports.
Like Botox and Dysport, Xeomin is made from proteins that form part of the toxin released by the botulinum organism but it does not cause infection or illness of any form. “Xeomin is also “naked,” meaning that there are no additives, just botulinum toxin type A. This may mean that there is less risk of developing antibodies against Xeomin than other available neurotoxins. The body develops antibodies in response to a foreign invader and attacks. In theory, antibodies could prevent a neurotoxin from having its desired effects. Dr. Calderon thinks there will be less drug resistance in this product and patients may not become drug resistant. The result of cosmetic treatment with Xeomin or Botox is relaxation of facial muscles giving you a more youthful or relaxed look.
Facial lines and wrinkles generally fade away in two to seven days. Results typically last three to four, sometimes longer, and the treatment can be repeated as needed.
Dr. Calderon was selected by the distributor to be one of the first physicians in Texas to try Xeomin because of her past experience and volume of work with cosmetic toxin and filler injections.
Like Botox and Dysport, Xeomin was initially approved for the treatment of blepharospasm and cervical dystonia, conditions that involve involuntary muscle spasms, to reduce abnormal head positioning, neck pain and eyelid spasms. The injectable wrinkle reducer is also now approved for the treatment of moderate to severe glabellar lines – those “11’s” that form between the eyebrows.
Xeomin contains a form of botulinum toxin known as incobotulinum toxin A, which varies slightly from the chemical composition of Botox and Dysport. When injected into the underlying muscle, Xeomin blocks the release of a wrinkle-causing chemical called acetylcholine. While Xeomin doesn’t prevent all facial muscles from contracting, it does decrease the force with which the targeted muscles contract when you scowl, sneeze or otherwise contort your face.
What It’s Good For
Xeomin is said to be a powerful treatment for glabellar lines, known as the vertical wrinkles or “11’s” between the eyebrows. Xeomin injections effectively reduce the appearance of “dynamic” wrinkles—those that become evident when you frown, squint and laugh.
Who It Works For
If you’re worried about your frown lines, then stop! Scowling can actually exacerbate these wrinkles. If you’re looking for a way to temporarily eliminate these lines, then Xeomin might just be it. The injectable wrinkle reducer can keep these creases at bay for up to four months.
Recommended Age Range
Xeomin is recommended in patients over the age of 18 and under 65.
When Will I See Results?
Initial studies have found that it takes approximately seven days to notice improvement after treatment with Xeomin. As with any injection, your muscles may become swollen or bruised afterward depending on your individual reaction.
How Long Will It Last?
Xeomin injections last an average of 12 weeks, according to clinical studies, though the product is still in trial stages in the US. Patients should wait at least 12 weeks before re-injecting an area with Xeomin.
Key Benefits Of Xeomin
Because of its chemical construction, Xeomin is said to be more “pure” than Botox and Dysport, meaning that allergic reaction is less likely. In addition, Xeomin does not have to be refrigerated, and it has a longer shelf life than its predecessors. With simpler storage requirements, Xeomin may be potentially cheaper once it hits the market—a bonus for your wallet.
Xeomin is manufactured by Merz Pharmaceuticals. With the new cosmetic approval, Xeomin now joins the ranks of Botox and Dysport. Other Botox alternatives, including a topical form of Botox, are currently being studied as well. Worldwide, more than 84,000 people have been treated with Xeomin injections. The U.S. is actually the 20th country to approve this new drug. It will be available in 50-unit and 100-unit vials.
Xeomin vs Botox, Dysport
All three approved neurotoxins are very similar, but they do have some important differences. The differences likely mean more to the physician or injector than the consumer. For example, Xeomin is the only one of the three that does not need to be refrigerated before use, which may simplify distribution.
The full effects of Xeomin occur within one week, and the results last from three to six months, making it comparable to Botox in terms of both onset and duration of action. Xeomin should not be used interchangeably with other botulinum products.
All botulinum products must carry a boxed warning, which is the strictest warning the FDA can mandate; Xeomin is no exception. There is a risk that all botulinum toxin products may spread from the area where they were injected to other parts of the body, causing potentially life-threatening swallowing and breathing problems. This was predominantly seen in children treated with Botox off-label for cerebral palsy. These issues have not been reported among people who received botulinum products for cosmetic uses or to treat blepharospasm.
Other risks may include bleeding and bruising at the injection site and allergic reactions such as itching, swelling or shortness of breath. Your doctor should discuss all the potential risks of this procedure with you during your consultation.
When Xeomin is used to treat cervical dystonia, side effects include neck pain, muscle weakness, injection site pain and musculoskeletal pain. When used to treat blepharospasm, the most common side effects of Xeomin were eyelid sagging, dry eye, dry mouth, diarrhea, headache, visual impairment, shortness of breath (dyspnea), and upper respiratory infections.